Latent transforming growth factor binding protein 4 regulates transforming growth factor beta receptor stability
نویسندگان
چکیده
منابع مشابه
Latent transforming growth factor binding protein 4 regulates transforming growth factor beta receptor stability.
Mutations in the gene for the latent transforming growth factor beta binding protein 4 (LTBP4) cause autosomal recessive cutis laxa type 1C. To understand the molecular disease mechanisms of this disease, we investigated the impact of LTBP4 loss on transforming growth factor beta (TGFβ) signaling. Despite elevated extracellular TGFβ activity, downstream signaling molecules of the TGFβ pathway, ...
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From the Department of Pathology, Division of Molecular and Cellular Pathology,* the BioMatrix Engineering and Regenerative Medicine Center, and the Departments of Pediatrics (Pulmonary Division), Cell Biology and Pathology, University of Alabama at Birmingham, Birmingham, Alabama; the Departments of Virology and Pathology, Haartman Institute, University of Helsinki, Helsinki, Finland; and the ...
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Latent-transforming growth factor beta-binding protein 3 (LTBP-3) is important for craniofacial morphogenesis and hard tissue mineralization, as it is essential for activation of transforming growth factor-β (TGF-β). To investigate the role of LTBP-3 in tooth formation we performed micro-computed tomography (micro-CT), histology, and scanning electron microscopy analyses of adult Ltbp3-/- mice....
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Latent transforming growth factor β-binding protein 4 (LTBP4) is an extracellular matrix molecule that is a member of important connective tissue networks and is needed for the correct folding and the secretion of TGF-β1. LTBP4 is downregulated in carcinomas of various tissues. Here we show that LTBP4 is also downregulated in adenocarcinomas and squamous cell carcinomas of the esophagus in vitr...
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ژورنال
عنوان ژورنال: Human Molecular Genetics
سال: 2015
ISSN: 0964-6906,1460-2083
DOI: 10.1093/hmg/ddv139